Arthritis manifests as an inflammation of joints depicted by their limited function and pain. At the preliminary stages of the condition, complete cure is possible but in later stages the resultant damage in irreversible even with rheumatological interventions. Its sufferers are men, women and children irrespective of their age, race and ethnicity. Arthritis occurs in different types.
Inflammatory types are systemic lupus erythematosus, gout, psoriatric and rheumatoid arthritis. Based on the type, different causes are identified. These include injury, genetic inheritance, abnormal metabolism, infections and an immune system that is overactive.
Common Causes of Arthritis
This is the main cause of degenerative arthritis. Injuries often create irregularities on the surfaces of smooth joints. Such injuries include fractures of the tibial plateau. Once broken, these joints allow cartilage entry to the injured region causing massive pain.
Occupational hazards for manual workers particularly in the construction industry are common. These make such individuals vulnerable to injury. High level sporting such as rugby and wrestling put participants in situations that can cause injuries. These injuries increase cartilage’s water content making the protein degenerate. Eventually this bone component creates tiny crevasses in the form of flakes that are painful.
Some forms of arthritis such as rheumatoid and osteoarthritis often are spread to subsequent offspring. Gene factors associated with increased risk to arthritis have been isolated. Although these speculations are not fully demystified, heredity studies and genetics have been associated to arthritis prevalence. Such genetic factors include MHC’s such as HLA-DR4 and HLA-DRB1. Although these factors are not key causatives, their presence accelerates this condition.
Infections caused by various microbes can induce septic arthritis. These include fungi, bacteria and viruses. Bacteria include Staphylococcus aureus, Pseudomonas species, Mycobacterium tuberculosis and E coli cause this condition.
Causative fungi include blastomyces, coccidiomyces and histoplasma species. Arthritis can also be sourced from viruses such as parvovirus B19, herpes, adenovirus, hepatitis B, C and A as well as coxsackie viruses among others.
All types of arthritis originate and worsen owing to calcium metabolism abnormalities. In this case, the body suffers of inadequate protein digestion, imbalance in the alkaline acid system, reduction in the phosphorous to calcium ratio and the presence or absence of some nutrients (vitamins and minerals). These metabolic dysfunctions induce bone resorption (the transfer of calcium and phosphorous from bone to blood) and a subsequent inflammation and bone weakening. With continued aging and weight gain, these abnormalities are likely to occur.
Immune System Over activity
Although the supposition that over-active immunological reactions induce arthritis remains less deciphered, it is highly likely to be the case. This is with the consideration that the immune system rarely targets joint and tissue inflammation. However, lymphocytes, which are immune cells often, enhance the activity of chemical messengers such as interleukins, tumor necrosis factors and cytokines whose high expression occurs in inflamed areas.
The 5 common causes of arthritis include genetic inheritance, injuries, abnormal immunological activities, abnormal metabolism and infections. However, the scope of arthritis causes is not limited to the aforementioned ones since environmental factors such as periodontal diseases; chemical (silica) exposure and smoking are causatives of this condition.